Abstract: The formation age and petrogenesis of the Yangkang granites in the Qilian block remain controversial. In this study, LA-ICP-MS zircon U-Pb dating and whole-rock geochemical analysis were conducted to constrain the petrogenetic and tectonic processes during the formation of the granites. The results show that U-Pb age of granodiorite in Yangkang pluton is 444±1.2Ma, (MSWD=1.14), indicating that it was formed in the early Late Ordovician and that the rocks belong to weak peraluminous-strong peraluminous I-type granite.The rocks are enriched with large ion lithophile elements (K,Ba, Rb) and Light Rare Earth Elements (LREEs) and Th, but depleted in the high field strength elements (e.g., Ta-Nb). The above results show that Yangkang granites were derived from partial melting of continental crust. Combined with the regional data, the authors suggest that the Yangkang granites were probably formed in an active continental margin during Late Ordovician.