Abstract: As an important part of the Tianshan metallogenic belt in Central Asia, Kyrgyzstan boasts rich mineral resources and completely types of mineral resources. The national scale (;1 000 000) geochemical mapping of Kyrgyzstan covers an area of about 170 000 km² across the country and the analyses and tests of 69 elements. It has filled in the blank of national geochemical mapping in Kyrgyzstan and will provide basic geochemical data for studies on basic geology, mineral development, environmental protection, and agricultural production inthe country. According to the regional geologic and structural evolution and geochemical background, the study area is divided into five structural geochemical regions. According to the geological background and the statistical analysis of geochemical parameters of major metallogenic elements, it is considered that Kyrgyzstan is a metallogenic favorable region of Au, Cu, Pb, Sb, Sn, W, and Ag, with notably distributed geochemical anomalies. In detail, the northern Tianshan Mountain shows high anomalies of Au, Cu, Pb, Zn, Ag, Be, and As. The middle Tianshan Mountaincan be divided into the eastern and western parts with the Fergana fault as the boundary. Among them, the western part is rich in Au, Cu, Cr, Mo, and Co, while the eastern part is rich in Au, W, Sn, Co, Cr, and Ni. As for the southern Tianshan Mountain, the western part is characterized by the concentrated distribution of Cu, Co, Cr, Ni, Au, As, Sb,and Hg, while the eastern part is characterized by the distribution of W, Sn, and Bi associations. The analytical results of metallogenic significance are as follows.The Chattkar area in middle Tianshan Mountain is considered the area with the highest prospecting potential in Kyrgyzstan. It has enormous potential for the prospecting of Cu, Pb, Au, and W. It is followed by the Zarejaz area in the eastern part of the southern Tianshan Mountain, which also has great prospecting potential and is highly favorable forthe prospecting of Au, CU, W, and Sn. Besides, the western part of the southern Tianshan Mountain and the Talas-Narun area also enjoygood prospecting potential and are prospecting favorable areas of gold, copper, lead, and zinc polymetallic deposits.