Abstract: The establishment of the Quaternary stratigraphic framework is of great significance for the study of regional stratigraphic correlation and paleogeographic environment evolution. The sedimentary strata since the Late Pleistocene have been extensively studied, but the research on the complete Quaternary stratigraphic framework is not yet sufficient. Therefore, paleomagnetic, AMS 14C, OSL, well logging, and lithostratigraphic studies were conducted on borehole QK4 (depth: 285.98 m) in the Lubei Plain. Based on the systematic paleomagnetic sampling (398 samples), processing, and testing, it is considered that the cores from borehole QK4 recorded Brunhes normal polarity chron, Maruyama reversed polarity chron, Gauss normal polarity chron, and some of their polarity subchrons. Based on the magnetic age framework, as well as MS 14C, OSL, well logging, and lithostratigraphic characteristics, the Quaternary strata revealed by borehole QK4 were divided, and it was determined that the bottom boundaries of the Holocene, Upper Pleistocene, Middle Pleistocene, and Lower Pleistocene strata have depths of 4.11 m, 23.49 m, 118.70 m, and 147.35 m, respectively. Moreover, as the strata revealed, the strata revealed by borehole QK4 include the Cenozoic Heituhu, Dazhan, Pingyuan, and Minghuazhen formations from top to bottom. The results allowed for the establishment of the Quaternary stratigraphic framework in the southern Lubei Plain, thus providing reliable petrological, chronological, and paleomagnetic evidence for the Quaternary stratigraphic division and correlation and palaeogeographic environmental evolution in the southern Lubei Plain.