Abstract: Sedimentary copper deposits are the predominant type of copper (cobalt) mineralization in the Central African copper-cobalt metallogenic belt. To improve the prospecting efficiency of such deposits, the feasibility of applying the hydrocarbon-mercury gas measurement method in the prospecting of sedimentary copper deposits was studied in the Mabende-Likasi area of the Democratic Republic of Congo. As indicated by the test results, two known ore bodies show remarkable anomalies of multiple indicators of hydrocarbon and mercury, but the anomaly distribution is controlled by the occurrence of orebodies. Based on these findings, this study summarized the anomaly pattern of hydrocarbon-mercury gas and primarily explored the anomaly causes. Moreover, this study conducted the prospecting prediction of concealed copper (cobalt) deposits in the study area. An industrial copper orebody was discovered through drilling in the delineated favorable target area, thus achieving achieved prospecting results.